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Recent activuty clear turn off turn on clinixal experience with cefpodoxime proxetil in acute otitis media. A single copy of these materials may be reprinted for noncommercial personal use only. The developed procedure allows us to obtain bette4 yields of cefpodoxime proxetil and to eliminate the final purification step by column chromatography, necessary during the synthesis of this antibiotic by the previously reported methods.